Molecular BiologybioRxivPreprint
Modelling human zygotic genome activation in 8C-like cells in vitro
Jasmin Taubenschmid, Maria Rostovskaya, Fátima Santos…·Wolf Reik
This paper identifies 8-cell like cells (8CLCs) in human naive stem cells that model zygotic genome activation, expressing ZGA markers and transposable elements, and can be manipulated to enhance ZGA-like transcription.
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