Kristine Degn

MAVISp: A Modular Structure-Based Framework for Protein Variant Effects

MAVISp provides a modular structural framework for analyzing protein variant effects, offering over eight million variants across 1000 proteins with curated data and a web server for accessibility.

In-Silico Stability Predictors: Investigation of Performance Towards balanced Experimental Data

The paper benchmarks protein stability predictors using a balanced dataset of AlphaFold structures, showing performance declines when balancing data and highlighting the benefits of molecular dynamics ensembles over static structures.

PDBminer to Find and Annotate Protein Structures for Computational Analysis

PDBminer provides an open-source tool to search and rank experimentally determined protein structures from PDB and AlphaFoldDB for computational analysis.

RosettaDDGPrediction for high-throughput mutational scans: from stability to binding

RosettaDDGPrediction enables high-throughput calculation of free energy changes from amino acid substitutions using Rosetta, with tools for data aggregation and visualization.

MutateX: an automated pipeline for in-silico saturation mutagenesis of protein structures and structural ensembles

MutateX automates in-silico saturation mutagenesis to predict free energy changes of protein mutations, supporting analysis of disease-associated mutations and protein design.