CD163 protects against pulmonary injury and inflammation induced by acute O3 exposure
Samuel J. Cochran, Brett Saunders, Evangeline Schott, Katelyn Dunigan, Grace Hutton, Aaron T. Vose, Anastasiya Birukova, Cameron Rankin, T. McMahon, Hongmei Zhu, Valery V. Khramtsov, Murugesan Velayutham, Salik Hussain, Robert M. Tighe, Kymberly M. Gowdy
This study shows that CD163 reduces O3-induced pulmonary injury by clearing cell-free hemoglobin (CFH), as demonstrated in mice and human samples.
bioRxiv · Jun 4, 2026 · PreprintPharmacology & Toxicology