Yanni Wang

This study evaluates Parent-of-Origin-Aware genomic analysis (POAga) to improve cascade testing in pancreatic cancer families by clarifying familial risk.

The paper sequences chromosome 21 centromeres in Down syndrome families, finding extreme size asymmetry in some cases and suggesting it may be a genetic risk factor.

The paper uses a four-generation family to systematically assess de novo mutations and recombination, finding high mutation rates and paternal bias, along with a detailed recombination map.

scDNAm-GPT is a foundation model for single-cell DNA methylation analysis that improves clustering, trajectory inference, and deconvolution using context-aware tokenization and attention mechanisms.