Membrane Lipid Composition and Asymmetry Act as a Switch for Cell-Penetrating Peptide Translocation versus Leakage
Èric Catalina-Hernández, Mateo Calle-Velasquez, Mohsen Habibnia, Marcel Aguilella‐Arzo, Ramon Barnadas‐Rodríguez, V. Lorenz, Alex Perálvarez‐Marín
This paper shows that membrane lipid composition and asymmetry determine whether a CPP translocates or causes leakage, using simulations and experiments.
bioRxiv · May 25, 2026 · PreprintBiophysics