ImmunologyCancer DiscoveryPeer-reviewed
Rational protein engineering to enhance MHC-independent T cell receptors
Ju-Fang Chang, Jack H. Landmann, Tien-Ching Chang…·Nathan Singh
The paper designs MHC-independent T cell receptors (miTCRs) to enhance cancer immunotherapy by improving receptor stability and function through structural modeling and iterative sequence modifications.
10 citations