Author

Eftychios Frangedakis

University of CambridgeORCID 0000-0002-3483-8464Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:plant (other)· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Jim P. HaseloffiD· 5 shared Facundo RomaniiD· 4 shared Alexandros Fragkidis· 1 shared Anthony West· 1 shared Carolina GrandellisiD· 1 shared Davide AnneseiD· 1 shared Edith C. F. ForestieriD· 1 shared Felipe Xavier BusoniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersPlant Biology

Jim P. HaseloffORCID

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5 papers

Recent·Most cited

Marchantia polymorpha as a simple platform for plant-based production of functional nanobodies

Sze Wai Tse, Facundo Romani, Fernando FGC Guzman Chavez, Eftychios Frangedakis, Jim P. Haseloff

This paper demonstrates the use of Marchantia polymorpha for producing functional nanobodies with high yield, comparable to Nicotiana benthamiana, offering a scalable and safe plant-based production platform.

bioRxiv · Jun 23, 2026 · PreprintPlant Biology

The ABCG1 transporter facilitates sesquiterpene accumulation in Marchantia polymorpha oil bodies.

Edith C. F. Forestier, Paola Asprilla, Ignacy Bonter, Facundo Romani, Eftychios Frangedakis, Jim P. Haseloff

The paper identifies ABCG1 as critical for sesquiterpene retention in Marchantia polymorpha oil bodies through overexpression and CRISPR disruption experiments.

Communications Biology · Mar 2, 2026Peer-reviewedPlant Biology

A tRNA-gRNA multiplexing system for CRISPR genome editing in Marchantia polymorpha.

Eftychios Frangedakis, Nataliya E. Yelina, Satish Kumar Eeda, Facundo Romani, Alexandros Fragkidis, Jim P. Haseloff, Julian M. Hibberd

This paper introduces a tRNA-gRNA multiplexing system for CRISPR genome editing in Marchantia polymorpha, improving efficiency and scalability of genome modifications.

Journal of Experimental Botany · Sep 29, 2025Peer-reviewedPlant Biology

Semi-automated workflow for high-throughput Agrobacterium-mediated plant transformation

Davide Annese, Facundo Romani, Carolina Grandellis, Lesley Ives, Eftychios Frangedakis, Felipe Xavier Buson, Jenny Molloy, Jim P. Haseloff

This paper presents a semi-automated protocol for Agrobacterium-mediated plant transformation in Marchantia polymorpha, improving efficiency and reducing costs for high-throughput experiments.

The Plant Journal · Apr 1, 2025Peer-reviewedSynthetic Biology

Systematic tools for reprogramming plant gene expression in a simple model, Marchantia polymorpha.

Susana Sauret-Gueto, Eftychios Frangedakis, Linda Silvestri, Marius Rebmann, Marta Tomaselli, Kasey Markel, Mihails Delmans, Anthony West, Nicola J. Patron, Jim P. Haseloff

The paper introduces the OpenPlant toolkit for bioengineering in Marchantia polymorpha, enabling efficient plant transformation and gene expression studies without specialized facilities.

ACS Synthetic Biology · Mar 12, 2020Peer-reviewedSynthetic Biology