Increased capacity to maintain glucose homeostasis in a transgenic mouse expressing human but not mouse growth hormone with developing high fat diet-related insulin resistance, steatosis and adipose dysfunction
Yan Jin, Jessica S. Jarmasz, Shakila Sultana, Luis Cordero-Monroy, Carla G. Taylor, Peter C. Zahradka, Elissavet Kardami, Peter A. Cattini
This study compares the effects of human and mouse growth hormone on glucose homeostasis in transgenic mice fed high fat diets, finding initial resistance to insulin resistance in human GH-expressing mice.
Journal of Molecular Endocrinology · Jun 4, 2024Peer-reviewedPhysiology