A universal polymer signature in Hi-C resolves cohesin loop density and supports monomeric extrusion
Kirill Polovnikov, Dmitry Starkov
The paper develops a polymer-physics framework to analyze Hi-C data and infers a conserved cohesin loop density of ~6 loops per megabase, supporting a predominantly monomeric mode of loop extrusion.
Proceedings of the National Academy of Sciences · Apr 15, 2026Peer-reviewedBiophysics