Kirill Polovnikov

The paper develops a kinetic theory of cohesin extrusion to explain loop statistics and fountain geometry, finding that cohesin crowding and roadblock dynamics determine loop lengths and arm coordination.

The paper assesses the sequencing depth requirements for Hi-C-derived metrics and finds that different metrics reach biologically meaningful accuracy at varying depths.

The paper develops a polymer-physics framework to analyze Hi-C data and infers a conserved cohesin loop density of ~6 loops per megabase, supporting a predominantly monomeric mode of loop extrusion.

The paper maps lipidomic and transcriptomic profiles in human brain regions, revealing distinct spatial patterns and three classes of lipid-gene relationships.

The paper shows mitotic chromosomes are self-entangled and disentangle through a Topoisomerase II-dependent two-stage process during mitotic exit.