Membrane partition and structural reorganization induced by anti-psychotics with distinct clinical profiles
Ana Gorše, Vesela Yordanova, Jessica Bodosa, Marion Mathelié‐Guinlet, Astrid Walrant, Nada Taib-Maamar, Axelle Grélard, Claire François-Martin, Rim Baccouch, Estelle Rascol, Gilmar F. J. Salgado, Maria João Moreno, Margarida Bastos, Jeffery B. Klauda, Galya Staneva, , Isabel D. Alves
This study compares how two antipsychotics, chlorpromazine and clozapine, partition into and modify lipid membranes, revealing differences in their membrane remodeling effects despite differing D2R antagonism strengths.
bioRxiv · Feb 10, 2025 · PreprintBiophysics