Author

Rim Baccouch

Lyon 1 UniversitéORCID 0009-0008-7828-3801Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ahcène BoumendjeliD· 2 shared Eleftherios ZarkadasiD· 2 shared Erwin LampingiD· 2 shared Guy SchoehniD· 2 shared Jorgaq PataiD· 2 shared Nour Samrouth· 2 shared Pierre FalsoniD· 2 shared Raphaël TerreuxiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Ahcène BoumendjelORCID

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3 papers

Recent·Most cited

The immunosuppressant tacrolimus (FK506) inhibits C. glabrata Cdr1 efflux pump function by stabilizing the inward-facing conformation.

Rim Baccouch, Theo Benefice, Eleftherios Zarkadas, Nour Samrouth, Jorgaq Pata, Sandrine Magnard, Florent Di Meo, Raphaël Terreux, Stephanie Aguero, Ahcène Boumendjel, Guy Schoehn, Erwin Lamping, Pierre Falson, Vincent Chaptal

This paper reveals that tacrolimus inhibits C. glabrata Cdr1 by stabilizing its inward-facing conformation, blocking ATP hydrolysis and azole transport.

bioRxiv · Jul 8, 2026 · PreprintBiochemistry

Cryo-EM of ATP-driven dynamics and itraconazole binding of the fungal drug efflux ABC pump Candida glabrata Cdr1

Jorgaq Pata, Benjamin Wiseman, Eleftherios Zarkadas, Rim Baccouch, Nour Samrouth, Celia Desbois, Loïck Moissonnier, Alexis Moréno, Atanu Banerjee, Stephanie Aguero, Emmanuel Bettler, Marie Dujardin, Sandrine Magnard, Raphaël Terreux, Guy Schoehn, , Pierre Falson

The paper presents cryo-EM structures of the fungal ABC pump Cdr1, revealing its ATP-driven dynamics and drug-binding mechanism.

bioRxiv · Sep 22, 2025 · PreprintBiochemistry

Membrane partition and structural reorganization induced by anti-psychotics with distinct clinical profiles

Ana Gorše, Vesela Yordanova, Jessica Bodosa, Marion Mathelié‐Guinlet, Astrid Walrant, Nada Taib-Maamar, Axelle Grélard, Claire François-Martin, Rim Baccouch, Estelle Rascol, Gilmar F. J. Salgado, Maria João Moreno, Margarida Bastos, Jeffery B. Klauda, Galya Staneva, , Isabel D. Alves

This study compares how two antipsychotics, chlorpromazine and clozapine, partition into and modify lipid membranes, revealing differences in their membrane remodeling effects despite differing D2R antagonism strengths.

bioRxiv · Feb 10, 2025 · PreprintBiophysics