A spatio-temporal model to reveal oscillatorphenotypes in molecular clocks: Parameterestimation elucidates circadian gene transcriptiondynamics in single-cells
Måns Unosson, Marco Brancaccio, Michael Harvey Hastings, Adam Michael Johansen, Bärbel Finkenstädt
The paper develops a spatio-temporal model to analyze circadian gene expression dynamics in single cells, revealing spatial and temporal differences in oscillation robustness and regulatory profiles in mouse SCN tissue.
PLoS Computational Biology · Dec 17, 2021Peer-reviewedSystems Biology