Fine-tuned Protein Language Model Identifies Antigen-specific B Cell Receptors from Immune Repertoires
Karen Paco, Mariana Paco Mendivil, Zihao Zhang, Sanaz Zebardast, C. Davila, R.F. Mooney, Peace O. Olatoyinbo, Tristan Yang, Sebastián Bassi, Virginia Gonzalez, Eva Chen, Faisal Bin Ashraf, Isabel Condori Roman, Jonathan R. Felix, Rashid M. Alam, , Animesh Ray
The paper introduces a protein language model fine-tuned to predict antigen-specific B cell receptors from immune repertoires, showing effectiveness across multiple antigens.
bioRxiv · Oct 30, 2025 · PreprintBioinformatics