Author

Karen Paco

Keck Graduate InstituteORCID 0009-0007-9638-5222Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Animesh RayiD· 2 shared Faisal Bin AshrafiD· 2 shared Jordan A. Lay· 2 shared Mariana Paco Mendivil· 2 shared Stefano LonardiiD· 2 shared Zihao ZhangiD· 2 shared C. DavilaiD· 1 shared Eva Chen· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Animesh RayORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 30, 2025

Fine-tuned Protein Language Model Identifies Antigen-specific B Cell Receptors from Immune Repertoires

Karen Paco, Mariana Paco Mendivil, Zihao Zhang…·Animesh Ray

The paper introduces a protein language model fine-tuned to predict antigen-specific B cell receptors from immune repertoires, showing effectiveness across multiple antigens.

DOI 10.1101/2025.10.30.685465

mouseproteomics

𝕏 PostBluesky

Molecular BiologybioRxivPreprintDec 19, 2024

A Large Language Model Guides the Affinity Maturation of Variant Antibodies Generated by Combinatorial Optimization

Faisal Bin Ashraf, Zihao Zhang, Karen Paco…·Stefano Lonardi

This paper introduces Ab-Affinity, a large language model that generates high-affinity antibodies against SARS-CoV-2 spike protein peptides using combinatorial optimization and AI.

2 citations

large language modeldrug response / drug discovery

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