Author

Zihao Zhang

Keck Graduate InstituteORCID 0000-0002-5898-7704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Animesh RayiD· 2 shared Faisal Bin AshrafiD· 2 shared Jordan A. Lay· 2 shared Karen PacoiD· 2 shared Mariana Paco Mendivil· 2 shared Stefano LonardiiD· 2 shared C. DavilaiD· 1 shared Eva Chen· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Animesh RayORCID

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2 papers

Recent·Most cited

Fine-tuned Protein Language Model Identifies Antigen-specific B Cell Receptors from Immune Repertoires

Karen Paco, Mariana Paco Mendivil, Zihao Zhang, Sanaz Zebardast, C. Davila, R.F. Mooney, Peace O. Olatoyinbo, Tristan Yang, Sebastián Bassi, Virginia Gonzalez, Eva Chen, Faisal Bin Ashraf, Isabel Condori Roman, Jonathan R. Felix, Rashid M. Alam, , Animesh Ray

The paper introduces a protein language model fine-tuned to predict antigen-specific B cell receptors from immune repertoires, showing effectiveness across multiple antigens.

bioRxiv · Oct 30, 2025 · PreprintBioinformatics

A Large Language Model Guides the Affinity Maturation of Variant Antibodies Generated by Combinatorial Optimization

Faisal Bin Ashraf, Zihao Zhang, Karen Paco, Mariana Paco Mendivil, Jordan A. Lay, Animesh Ray, Stefano Lonardi

This paper introduces Ab-Affinity, a large language model that generates high-affinity antibodies against SARS-CoV-2 spike protein peptides using combinatorial optimization and AI.

bioRxiv · Dec 19, 2024 · PreprintMolecular Biology