Norbert R. Nowotny

IFIH1 loss-of-function predisposes to inflammatory and SARS-CoV-2-related infectious diseases

This study identifies IFIH1 loss-of-function variants in patients with inflammatory and SARS-CoV-2-related diseases, showing impaired immune responses and increased susceptibility.

Genetic determinants of severe COVID-19 in young Asian and Middle Eastern patients

This study identifies rare genetic variants associated with severe COVID-19 in young Asian and Middle Eastern patients using whole exome sequencing.

Genomic and phenotypic characterization of Multisystem Inflammatory Syndrome in Children (MIS-C): a prospective multicenter study from the Middle East

This study identifies rare genetic variants in MIS-C patients from the Middle East, linking them to disease onset and treatment resistance.

Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes

The paper identifies molecular signatures and dysregulated pathways in COVID-19 patients with varying disease severity using transcriptome sequencing of nasopharyngeal swabs.

Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East

The paper analyzes SARS-CoV-2 genome sequences from Dubai to show multiple introductions from Asia, Europe, and the Middle East during the early pandemic and identifies new mutations.

SARS-CoV-2 Whole Genome Amplification and Sequencing for Effective Population-Based Surveillance and Control of Viral Transmission

This study compares whole genome sequencing methods for SARS-CoV-2, showing improved detection and cost-effectiveness with target enrichment.