Repeat-driven generation of antigenic diversity in a major human pathogen, Trypanosoma cruzi
Carlos N. Talavera-López, Louisa Alexandra Messenger, Michael D. Lewis, Matthew Yeo, João Luís Reis-Cunha, Gabriel Machado Matos, Daniella Castanheira Bartholomeu, José E. Calzada, Azäel Saldaña, Juan David Ramírez, Felipe Guhl, Sofía Ocaña-Mayorga, Jaime Alfredo Costales, Rodion V. Gorchakov, Kathryn Marie Jones, , Björn Andersson
The paper presents an improved genome assembly of Trypanosoma cruzi and reveals a unique genomic structure involving subtelomeric regions and retrotransposons contributing to antigenic variation.
Frontiers in Cellular and Infection Microbiology · Mar 3, 2021Peer-reviewedGenomics