Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacity
Kevin C.L. Cheng, Zoe P. Klein, Jigyansa Mishra, Alexander T. Bahcheli, Benjamin Hoyin Lok, Trevor J. Pugh, Jüri Reimand
The paper examines therapy-associated mutagenesis at CTCF binding sites across 4,870 tumor genomes, finding increased mutation enrichment at these sites under radiotherapy and trifluridine treatment.
bioRxiv · Apr 18, 2026 · PreprintCancer Biology