Jigyansa Mishra

Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases

This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.

Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacity

The paper examines therapy-associated mutagenesis at CTCF binding sites across 4,870 tumor genomes, finding increased mutation enrichment at these sites under radiotherapy and trifluridine treatment.

Pairwise genomic alterations identify prognostic tumor states in multiple cancer types

The paper identifies prognostic genomic interactions (PGIs) across multiple cancer types by analyzing pairwise genomic alterations and their association with patient outcomes.

Mutational signatures in cancer genomes alter protein sequence motifs in cellular signaling networks

The paper identifies mutational signatures in cancer genomes that alter protein sequence motifs in signaling networks, linking mutation etiology to functional consequences.