Chikungunya Virus Infection of Monocytes Generates a Persistent Macrophage Reservoir That Promotes IFN-π/IL-27-STAT1- and NF-κB-Driven Chronic Arthritis
Juan Felipe Valdés‐López, Yordi Sebastián Tamayo-Molina, Lady Johana Hernández-Sarmiento, Silvio Urcuqui Inchima
This study shows CHIKV infection transforms monocytes into persistently infected macrophages that drive chronic arthritis through IFN-π/IL-27-STAT1 and NF-κB pathways.
bioRxiv · Sep 30, 2026 · PreprintBioinformatics