Silvio Urcuqui Inchima

A TLR2-associated entry pathway promotes productive dengue virus serotype 2 infection and inflammatory responses in classical monocytes

This study shows that TLR2 promotes DENV2 infection and inflammation in classical monocytes, with subset-specific effects and implications for endothelial barrier disruption.

Chikungunya Virus Infection of Monocytes Generates a Persistent Macrophage Reservoir That Promotes IFN-π/IL-27-STAT1- and NF-κB-Driven Chronic Arthritis

This study shows CHIKV infection transforms monocytes into persistently infected macrophages that drive chronic arthritis through IFN-π/IL-27-STAT1 and NF-κB pathways.