Neerja Bhatla

The paper investigates the role of upregulated GRP78 and sFlt-1 in preeclampsia, showing their induction of IRE1 and ATF6 arms of UPR and ER stress in placental cells through in vitro experiments.

This study examines MMP-9 and TIMP-1 expression in placentae of early-onset preeclampsia patients compared to controls, finding altered expression levels associated with impaired placentation.

The paper compares MMPs, TIMPs, CBS, Sp1, and miR-22 expression in EOPE patients and controls, finding significant downregulation of MMPs, CBS, and Sp1 and upregulation of TIMPs and miR-22.

This study investigates the miR-22/Sp1/CBS axis in regulating trophoblast invasion using in vitro experiments with HTR-8/SVneo cells.

The paper investigates the expression levels of MMPs 2, 9, TIMPs 1, 2, CBS, Sp1, and miR-22 in early onset preeclampsia and normotensive controls, finding reduced MMPs and CBS/Sp1 with increased TIMPs and miR-22 in preeclamptic patients.

The paper shows that sFlt-1 from preeclamptic pregnancies induces endoplasmic reticulum stress in trophoblast cells through increased expression of ER stress markers.

This study shows that sFlt-1 increases ER stress markers in trophoblast cells, linking it to preeclampsia complications.