Zhichao Xu

The paper introduces an R2 total mediation effect measure for binary traits in case-control studies with high-dimensional mediators, showing 89% of BMI's effect on CHD is mediated by metabolomics.

The paper develops a meta-analysis framework for estimating total mediation effects with high-dimensional omics mediators using summary statistics, applied to TOPMed data to study gene expression's role in blood pressure and HDL cholesterol variation.

The paper introduces a cross-fitted estimation procedure for R2-based mediation effects in high-dimensional mediators, showing improved computational efficiency while maintaining statistical accuracy.

The paper introduces MRFscRNAseq, a Markov Random Field model for identifying cell-type specific differentially expressed genes in scRNA-seq data, showing improved power over conventional methods.