Electrostatic Self-Assembly of Protein Nanoparticles from Intrinsically Disordered Polypeptide and Globular Protein Pairs
So Yeon Ahn, Megan S.K. Jen, Dayoung Gloria Lee, Jake D. Johnston, Jane Liao, Eun Sol Kim, Ying Tong Yue, Shana Elbaum‐Garfinkle, Oleg Gang, Allie C. Obermeyer
This paper develops a platform for creating protein nanoparticles using electrostatic interactions between globular proteins and intrinsically disordered polypeptides, enabling controlled delivery of functional proteins.
bioRxiv · Jan 8, 2026 · PreprintBioengineering