Klaus Winzer

This paper develops methods to apply transposon-insertion sequencing in Clostridium autoethanogenum to identify essential genes for growth using carbon monoxide.

This study compares thermodynamics-based flux analysis and metabolic flux analysis in Escherichia coli using experimental data to evaluate their predictive capabilities and identify limitations.

The paper introduces a test-driven framework for developing and maintaining genome-scale metabolic models, enabling continuous integration of validation data and improving model reliability.