Author

Yuta Isaka

RIKEN Center for Computational ScienceORCID 0000-0002-3974-0650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1

Frequent Co-Authors

Gert‐Jan BekkeriD· 1 shared Hironori KokuboiD· 1 shared Kazuhiro TakemuraiD· 1 shared Mitsugu ArakiiD· 1 shared Mitsunori IkeguchiiD· 1 shared Narutoshi KamiyaiD· 1 shared Shigeyuki MatsumotoiD· 1 shared Toru EkimotoiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Gert‐Jan BekkerORCID

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1 paper

Recent·Most cited

Molecular dynamics unveils multiple-site binding of inhibitors with reduced activity on the surface of dihydrofolate reductase

Mitsugu Araki, Toru Ekimoto, Kazuhiro Takemura, Shigeyuki Matsumoto, Yunoshin Tamura, Hironori Kokubo, Gert‐Jan Bekker, Tsutomu Yamane, Yuta Isaka, Yukari Sagae, Narutoshi Kamiya, Mitsunori Ikeguchi, Yasushi Okuno

This study uses molecular dynamics to analyze inhibitor binding to DHFR, showing that reduced activity correlates with multiple-bound states on the protein surface.

Journal of the American Chemical Society · Oct 12, 2024Peer-reviewedBiophysics