In silico screening of TMPRSS2 SNPs that affect its binding with SARS-CoV2 spike protein and directly involved in the interaction affinity changes
Fatma Nouira, Manel Hamdi, Alaeddine Redissi, Soumaya Kouidhi, Chérine Charfeddine, Meriem M’saad, Ameur Cherif, Sabri Messaoudi, Sarah Aldulaijan, Noureddine Raouafi, Adnène Dhouib, Amor Mosbah
The paper identifies 17 TMPRSS2 SNPs affecting binding with SARS-CoV2 spike protein, with four increasing and two decreasing interaction affinity, linked to population-specific genetic factors.
bioRxiv · Sep 29, 2021 · PreprintBioinformatics