Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data.
Paweł Dudzic, Dawid Chomicz, Weronika Bielska, Igor Jaszczyszyn, Michał Zieliński, Bartosz Janusz, Sonia Wróbel, Marguerite-Marie Le Pannérer, Andrew Phillips, Ponraj Prabakaran, Sandeep Kumar, Konrad Krawczyk
PairedAbNGS pools 58 single-cell bioprojects of natural paired human and mouse antibodies, revealing heavy/light V gene pairing biases beyond usage frequencies and conserved CDR3-FWR2 inter-chain contacts.
Communications Biology · Jul 26, 2025Peer-reviewedImmunology✦ In-depth digest