Deepak K. Rajpal

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity

The paper identifies inverted D genes and D-D fusions in human antibody repertoires, revealing new diversity and functionality through a comprehensive analysis of NGS data.

Leveraging large-scale multi-omics to identify therapeutic targets from genome-wide association studies

This study identifies therapeutic targets by integrating GWAS with multi-omics data, finding enriched causal genes and novel associations like IL6ST in polymyalgia rheumatica.

Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson's Disease and Multiple System Atrophy

The paper profiles single nuclei from human putamen in Parkinson's Disease and Multiple System Atrophy, revealing disease-specific oligodendrocyte heterogeneity and gene expression changes.

Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson's Disease and Multiple System Atrophy

The paper constructs a single-cell atlas of human putamen tissue from healthy controls, Parkinson's Disease, and Multiple System Atrophy to identify cell-type specific disease changes.

Atlas of epistasis

The paper identifies genome-wide significant epistasis interactions across 502 phenotypes using UK Biobank data and replicates some in Finngen consortium cohorts, revealing common variants' roles in complex diseases.

Lysosomal-Immune Axis Is Associated with COVID 19 Disease Severity: Insights from Patient Single Cell Data

The paper analyzes single-cell RNA-seq data from COVID-19 patients to identify the lysosomal-immune axis as a factor associated with disease severity.

Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson's Disease Risk

This paper computes a genome-wide polygenic risk score for Parkinson's Disease using 6.2 million variants and finds it strongly associates with increased disease risk and earlier onset.

A tissue- and organ-based cell biological atlas of obesity-related human genes and cellular pathways

The paper constructs a tissue- and organ-based subcellular-function atlas of obesity-related genes and pathways using publicly available datasets and integration methods.