CD4+ tumor-infiltrating lymphocytes secreting T cell-engagers induce regression of autologous patient-derived non-small cell lung cancer xenografts
Anaïs Jiménez-Reinoso, Magdalena Molero-Abraham, Cristina Cirauqui, Belén Blanco, Eva Maria Garrido-Martin, Daniel Nehme-Álvarez, Carmen Domínguez-Alonso, Ángel Ramírez-Fernández, Laura Díez-Alonso, Ángel Nuñez-Buiza, África González‐Murillo, Raquel Tobes, Eduardo Pareja, Manuel R. Ramírez, José Luis Rodríguez‐Peralto, , Luis Álvarez‐Vallina
This study shows that engineered CD4+ TIL secreting TCE can induce tumor regression in NSCLC PDX models by redirecting non-tumor dominant T cell clones.
OncoImmunology · Aug 27, 2024Peer-reviewedCancer Biology