Evolutionary insights from profiling LINE-1 activity at allelic resolution in a single human genome
Lei Yang, Genevieve A. Metzger, Ricky Padilla Del Valle, Diego Delgadillo Rubalcaba, Richard N. McLaughlin
The paper profiles LINE-1 activity at allelic resolution in a single human genome, finding that some LINE-1s are active in vitro but not in vivo, and some old LINE-1s retain activity and may be adaptive.
The EMBO Journal · Dec 18, 2023Peer-reviewedGenetics