RNA expression data suggest ALDH2 inhibition as a concept for killing acute myeloid leukemia cells that are resistant to ALDH1 inhibitors: the example of NPM1 mutant AML
Régis T. Costello, Garrett Marc Dancik, Anaïs Dubiau, Lamia Madaci, Spiros Vlahopoulos
The paper analyzes RNA expression data to show that ALDH2 is more prognostically significant than ALDH1A1 in NPM1 mutant AML, suggesting ALDH2 inhibition as a potential therapeutic strategy.
Cells · Jul 7, 2025Peer-reviewedGenetic & Genomic Medicine