Molecular BiologybioRxivPreprint
Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome
Francisco Miguel Cruz, Álvaro Macías, Ana I. Moreno-Manuel…·José Jalife
This paper shows that a mutation breaking the Cys122-to-Cys154 disulfide bond in Kir2.1 channels disrupts PIP2 binding and causes arrhythmias in Andersen-Tawil Syndrome.
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