GenomicsBriefings in BioinformaticsPeer-reviewed
sciCNV: High-throughput paired profiling of transcriptomes and DNA copynumber variations at single cell resolution
Ali Mahdipour–Shirayeh, Natalie Erdmann, Chungyee Leung-Hagesteijn, Rodger Edwin Tiedemann
The paper introduces normalization methods and a pipeline for detecting DNA copy number variations alongside transcriptomes in single cells, applied to multiple myeloma to study the effects of +8q CNVs.