Author

Grzegorz Wieczorek

Molecure SA (Poland)ORCID 0000-0002-4227-3440Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Agnieszka BartoszewicziD· 1 shared Anna Antosiewicz· 1 shared Dorota NiedziałekiD· 1 shared Jacek OlczakiD· 1 shared Katarzyna Drzewicka· 1 shared Mariusz MilewskiiD· 1 shared Zbigniew ZasłonaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Agnieszka BartoszewiczORCID

Mutual co-authors in cluster

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1 paper

Recent·Most cited

Mechanism of catalytic apparatus of human chitotriosidase-1 and its dual inactivation mode by the first-in-class OATD-01 inhibitor.

Dorota Niedziałek, Grzegorz Wieczorek, Katarzyna Drzewicka, Anna Antosiewicz, Mariusz Milewski, Agnieszka Bartoszewicz, Jacek Olczak, Zbigniew Zasłona

This study models the catalytic mechanism of human chitotriosidase-1 using structural data and simulations, and shows how the OATD-01 inhibitor disrupts enzyme function through dynamic changes.

ACS Catalysis · Sep 19, 2025Peer-reviewedBiophysics