Mechanism of catalytic apparatus of human chitotriosidase-1 and its dual inactivation mode by the first-in-class OATD-01 inhibitor.
Dorota Niedziałek, Grzegorz Wieczorek, Katarzyna Drzewicka, Anna Antosiewicz, Mariusz Milewski, Agnieszka Bartoszewicz, Jacek Olczak, Zbigniew Zasłona
This study models the catalytic mechanism of human chitotriosidase-1 using structural data and simulations, and shows how the OATD-01 inhibitor disrupts enzyme function through dynamic changes.
ACS Catalysis · Sep 19, 2025Peer-reviewedBiophysics