The onset and offset of noxious stimuli robustly modulate perceived pain intensity
Benedict J. Alter, Mya Sandi Aung, Irina A. Strigo, Howard L. Fields
This study shows that changes in noxious stimulus intensity, whether increasing or decreasing, significantly affect perceived pain intensity, with onset hyperalgesia and offset analgesia occurring bidirectionally.
PLoS ONE · Dec 8, 2020Peer-reviewedNeuroscience