Author

Manali Joshi

Savitribai Phule Pune UniversityORCID 0000-0002-4255-2474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Lumbini R. Yadav· 1 shared Shekhar C. MandeiD· 1 shared Shruti B Chauhan· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Lumbini R. Yadav

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1 paper

Recent·Most cited

Structural basis of half-site reactivity in the catalytic α-subunit of Class Ib ribonucleotide reductases

Lumbini R. Yadav, Shruti B Chauhan, Manali Joshi, Shekhar C. Mande

The paper determines cryo-EM structures of Class Ib RNR catalytic α-subunit in apo and holo states, revealing asymmetric nucleotide binding and conformational dynamics that drive half-site reactivity.

bioRxiv · Jun 17, 2026 · PreprintBiophysics