Shekhar C. Mande

This study shows that the scaffold nucleoporin Nup188 can form liquid-liquid phase separation condensates, and Nup93 binding suppresses this process.

The paper determines cryo-EM structures of Class Ib RNR catalytic α-subunit in apo and holo states, revealing asymmetric nucleotide binding and conformational dynamics that drive half-site reactivity.

This paper uses cryo-EM to reveal the dynamic conformational landscape and C-terminal gating mechanism of a mycobacterial class Ib ribonucleotide reductase, showing multiple subunit association states and structural flexibility.

CoRNeA predicts protein-protein interaction interfaces from amino acid sequences using co-evolution, machine learning, and network analysis, achieving higher precision and recall in eukaryotic complexes.