Selective loss of Y chromosomes in lung adenocarcinoma modulates the tumor immune environment through cancer/testis antigens
Jonas Fischer, Katherine Hoff Shutta, Chen Chen, Viola Fanfani, Enakshi Saha, Panagiotis Mandros, Marouen Ben Guebila, Joanne Xiu, Jorge J. Nieva, Stephen V. Liu, Dipesh Uprety, David B. Spetzler, Camila M. Lopes‐Ramos, Dawn Lisa DeMeo, John F Quackenbush
This study investigates how loss of the Y chromosome in lung adenocarcinoma affects the tumor immune environment and response to immunotherapy.
bioRxiv · Sep 19, 2024 · PreprintCancer Biology