Methylglyoxal is the main culprit to impairing neuronal function: mediated through tryptophan depletion.
Md. Samsuzzaman, Jae Hyuk Lee, Seong‐Min Hong, Hyun Jun Park, Keun‐A Chang, Hyun-Bum Kim, Myoung Gyu Park, Hyeyoon Eo, Myung Sook Oh, Sun Yeou Kim
This study shows that methylglyoxal impairs neuronal function and induces depression by depleting tryptophan and disrupting its metabolism in the brain and intestine.
bioRxiv · Mar 29, 2023 · PreprintNeuroscience