Guang Shi

Loop Extrusion Reversal by Condensin Motor is Mediated by Catch Bonds

The paper develops a theory to explain condensin's forward and backward steps during loop extrusion, revealing catch bond-like behavior under mechanical force.

Connecting multiway enhancer-promoter interactions to changes in gene expression in cancer

The paper develops an AMC model to link multiway enhancer-promoter contacts and enhancer activity to gene overexpression in prostate and breast cancer.

Epigenetic state encodes locus-specific chromatin mechanics

This study develops a theory to infer locus-specific chromatin viscoelasticity from 3D genome organization and finds that mechanical properties are determined by both chromatin epigenetic marks and organization.

Static Three-Dimensional Structures Determine Fast Dynamics Between Distal Loci Pairs in Interphase Chromosomes

The paper develops a theory to predict chromatin dynamics using static 3D structures, showing that fast enhancer-promoter dynamics and scaling relationships are determined by chromatin organization.