Dynamic DnaA-DnaB interactions at oriC coordinate the loading and coupled translocation of two DnaB helicases for bidirectional replication
Takumi Tsuruda, Ryusei Yoshida, Chihiro Hayashi, Kazutoshi Kasho, Shogo Ozaki, Tsutomu Katayama
The paper identifies DnaB Thr86 as critical for strand-specific helicase loading and bidirectional replication coordination via low-affinity DnaA-DnaB interactions.
Nucleic Acids Research · Dec 12, 2025Peer-reviewedMolecular Biology