Author

Xinyuan Guan

University of Hong KongORCID 0000-0002-4485-6017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Victor Ho-Fun LeeiD· 2 shared Bin Yan· 1 shared Chiea Chuen KhoriD· 1 shared Chun-Ling LuoiD· 1 shared Dan YuiD· 1 shared Dongmei ChiiD· 1 shared Dora Lai‐Wan KwongiD· 1 shared Evelyn Yilin Wang· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

Victor Ho-Fun LeeORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 3, 2026

Foundation Model RNAGAN Enhances Biomedical Insight of Nasopharyngeal Carcinoma Metastasis

Zhaozheng Hou, Yijia Qian, Victor Ho-Fun Lee…·Wei Dai

This study applies the RNAGAN foundation model to nasopharyngeal carcinoma to identify metastasis markers and mechanisms, revealing a protective role of adaptive immune responses over innate inflammation.

DOI 10.64898/2026.07.02.736240

humanscRNA-seq

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Cancer BiologybioRxivPreprintFeb 5, 2026

Integrative Multi-Omics Analysis Identifies a Functional Enhancer Driving Tumorigenesis in Head and Neck Squamous Cell Carcinoma

Pengfei Xu, Xiaorong Liu, Jane Jingya Pu…·Junwen Wang

The paper identifies a functional enhancer, GH05J001312, that drives tumorigenesis in HNSCC by enhancing TERT expression and affecting cancer-related pathways.

DOI 10.64898/2026.02.03.703438

humanATAC-seq

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Genetic & Genomic MedicinemedRxivPreprintOct 14, 2025

Germline genetic risk converges through intercellular crosstalk in tumor microenvironment

Xiaomeng Bai, Yang Liu, Shuai He…·Yanni Zeng

The paper integrates genetic and transcriptomic data to show that germline variants influence tumor microenvironment cell interactions and prognosis in nasopharyngeal carcinoma.

DOI 10.1101/2025.10.14.25337882

humanbulk RNA-seq

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