Victor Ho-Fun Lee

This study applies the RNAGAN foundation model to nasopharyngeal carcinoma to identify metastasis markers and mechanisms, revealing a protective role of adaptive immune responses over innate inflammation.

RNAGAN is an AI tool that enhances transcriptomic analysis with interpretability and small data capability through a GAN structure trained on human RNA-seq data.

The paper identifies a functional enhancer, GH05J001312, that drives tumorigenesis in HNSCC by enhancing TERT expression and affecting cancer-related pathways.

The paper develops and validates multi-ancestry polygenic risk scores for LUAD in East Asian never-smokers, showing improved risk prediction compared to East Asian-only models.