Deep autoencoder for interpretable tissue-adaptive deconvolution and cell-type-specific gene analysis
Yanshuo Chen, Yixuan Wang, Yuelong Chen, Yuqi Cheng, Yumeng Wei, Yunxiang Li, Jiuming Wang, Yingying Wei, Ting‐Fung Chan, Yu Li
TAPE deconvolves bulk RNA-seq data into cell-type fractions and gene expression using a deep autoencoder, showing better performance and robustness compared to existing methods.
Nature Communications · Nov 8, 2022Peer-reviewedBioinformatics