Therapy-Induced Clonal Selection as a Driver of Response to JAK Inhibitors in Myelofibrosis
Sebastiano Rontauroli, Chiara Carretta, Matteo Bertesi, Sandra Parenti, Daniela Benati, Monica Maccaferri, TOMMASO FERRARI, Marica Malerba, Anita Neroni, Elisa Papa, Ruggiero Norfo, Margherita Mirabile, Lara Tavernari, Camilla Tombari, Paola Guglielmelli, , Rossella Manfredini
This study investigates clonal dynamics in myelofibrosis patients responding to JAK inhibitors, finding that mutation acquisition order and co-mutation status influence treatment sensitivity and disease persistence.
bioRxiv · Jun 23, 2026 · PreprintCancer Biology