Linkage-based ortholog refinement in bacterial pangenomes with CLARC
Indra González Ojeda, Samantha G. Palace, Pamela P. Martinez, Taj Azarian, Lindsay R. Grant, Laura L. Hammitt, William Paul Hanage, Marc Lipsitch
CLARC refines bacterial ortholog groups by integrating linkage and annotation data, reducing accessory gene estimates and improving evolutionary predictions in Streptococcus pneumoniae.
Nucleic Acids Research · Jun 18, 2025Peer-reviewedBioinformatics