Author

Yanfeng Xing

University of ChicagoORCID 0000-0002-4549-8370Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jack W. SzostakiD· 1 shared Xiwen JiaiD· 1 shared Ziyuan FangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

Jack W. SzostakORCID

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1 paper

Recent·Most cited

Nonenzymatic RNA copying with a potentially primordial genetic alphabet

Ziyuan Fang, Xiwen Jia, Yanfeng Xing, Jack W. Szostak

This paper investigates a primordial genetic alphabet using 2-thiouridine (s2U), 2-thiocytidine (s2C), inosine (I), and adenine (A), showing that their base pairs are isoenergetic and isomorphic, enabling balanced nucleotide incorporation in nonenzymatic RNA copying.

Proceedings of the National Academy of Sciences · May 21, 2025Peer-reviewedBiochemistry